Allowance for this should be made in evaluating the merits of the variety.
The approach is on a commercial basis and the method is not intended for use in evaluating small samples.
Patients will be enrolled regardless of their hyaluronan (HA) level, with analysis conducted retrospectively on a subset population of HA-high patients identified using the Ventana HA companion diagnostic assay. The collaboration between Halozyme and Genentech includes testing the experimental combination in MORPHEUS, Novel Cancer Immunotherapy Development Platform.
HA is a glycosaminoglycan, or chain of natural sugars in the body that can accumulate around cancer cells creating high pressure in a tumor, constricting blood flow and thereby reducing access of chemotherapy and immunotherapeutic agents. MORPHEUS is a Phase 1b/2 adaptive platform to develop combinations of cancer immunotherapies more rapidly and efficiently.
cerebrate, cogitate, think - use or exercise the mind or one's power of reason in order to make inferences, decisions, or arrive at a solution or judgments; "I've been thinking all day and getting nowhere"appraise, assess, evaluate, valuate, value, measure - evaluate or estimate the nature, quality, ability, extent, or significance of; "I will have the family jewels appraised by a professional"; "access all the factors when taking a risk"think, believe, conceive, consider - judge or regard; look upon; judge; "I think he is very smart"; "I believe her to be very smart"; "I think that he is her boyfriend"; "The racist conceives such people to be inferior"Managing a successful turnaround even in tight capital markets: the team navigating a turnaround must go way beyond reducing headcount alone and focus on seven steps to change the company's direction and improve its cash flow and profitability Does your core sand measure up?
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co.
Evaluation is the structured interpretation and giving of meaning to predicted or actual impacts of proposals or results.
It looks at original objectives, and at what is either predicted or what was accomplished and how it was accomplished.
The process of gathering, evaluating, and organizing material may best be shown by a concrete example.We review methods and conditions sufficient for accurate estimation within the proposed framework.We used the framework to analyze data on 2,329 participants in the Centers for AIDS Research Network of Integrated Clinical Systems to evaluate the impact of universal prescription of and ≥95% adherence to antiretroviral therapy on racial disparities in HIV virologic suppression. The combination will be tested in patients with previously treated metastatic pancreatic ductal adenocarcinoma. The study is part of a clinical collaboration agreement announced by the companies last year to evaluate PEGPH20 and atezolizumab in up to eight tumor types, including pancreatic and gastric cancers.The Phase 1b/2, open-label, multicenter, randomized clinical trial is designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of immunotherapy-based treatment combinations compared with the standard chemotherapy regimens.Reducing human immunodeficiency virus (HIV) racial/ethnic disparities is a high priority.